Carlos Priminho Pirovani
Fellow Research Productivity of CNPq – Level 1D

Full Professor

Campus Soane Nazaré de Andrade, Rodovia Jorge Amado, Km 16, Bairro Salobrinho CEP 45662-900. - Ilhéus/BA

(+55 73) 3680 5432 / 5226 (fax)

Academic Background

Graduate in Agronomy (1997), Master in Plant Physiology (emphasis on molecular biology) (1999) by the Federal University of Viçosa, Brazil and, PhD in Genetics and Molecular Biology (2008) by the State University of Campinas, Brazil.


Teaching experience

Teaches in undergraduate and graduate courses of Molecular Genetics (Undergraduate), Structure and Function of Macromolecules and, Protein Characterization (Graduate program).

Interest in Research

Research interests


Yours projects has been about molecular phytopathology. Two principal themes are proteases and proteases inhibitor engaged in the interaction between Theobroma cacao and Moniliophthora perniciosa, the causal agent of witches’ broom disease from cocoa and; the pre-infection mechanisms involved in the T. cacao-M. perniciosa pathosystem. Generally, yours researches use the genomic and proteomic approach, as well as post genomic analyzes directed to the characterization of isolated genes or biochemical and functional characterization of proteins. The genes and proteins of the host plant and the pathogen are analyzed to elucidate their functions in the pathosystem and to explore their biotechnological potential.



He is the coordinate of the Genomic and proteomic laboratory from Biotechnology and Genetics Center, State University of Santa Cruz, Ilhéus, Bahia Brazil. The proteomics analysis used in laboratory is based in 2D-SDS PAGE associated with in tandem nanochromatography connected to Q-TOFF Micro mass spectrometer. The genomic analysis is based in a MiSeq platform (Illumina).


Student supervision

He has supervised 6 PhD students and 14 Masters Research students. Currently, he supervises 3 PhD students and 3 Master research students.

Most Relevant Articles

Mares JH, Gramacho KP, Santos EC, da Silva Santiago A, Santana JO, de Sousa AO, Alvim FC, Pirovani CP. 2017. Proteomic analysis during of spore germination of Moniliophthora perniciosa, the causal agent of witches' broom disease in cacao. BMC Microbiol. 17(1):176.


Almeida DSM, Gramacho KP, Cardoso THS, Micheli F, Alvim FC, Pirovani CP. Cacao Phylloplane: The First Battlefield against Moniliophthora perniciosa, Which Causes Witches' Broom Disease. Phytopathology. 2017 Jul;107(7):864-871.


Santana JO, Freire L, de Sousa AO, Fontes Soares VL, Gramacho KP, Pirovani CP. 2016. Characterization of the legumains encoded by the genome of Theobroma cacao L. Plant Physiol Biochem. 98:162-70.


Cardoso TH, Freitas AC, Andrade BS, Sousa AO, Santiago Ada S, Koop DM, Gramacho KP, Alvim FC, Micheli F, Pirovani CP. 2015. TcCYPR04, a Cacao Papain-Like Cysteine-Protease Detected in Senescent and Necrotic Tissues Interacts with a Cystatin TcCYS4. PLoS One. 10(12):e0144440.


Freitas AC, Souza CF, Monzani PS, Garcia W, de Almeida AA, Costa MG, Pirovani CP. 2015. The activity of TcCYS4 modified by variations in pH and temperature can affect symptoms of witches' broom disease of cocoa, caused by the fungus Moniliophthora perniciosa. PLoS One. 10(4):e0121519.


Camillo LR, Filadelfo CR, Monzani PS, Corrêa RX, Gramacho KP, Micheli F, Pirovani CP. 2013. Tc-cAPX, a cytosolic ascorbate peroxidase of Theobroma cacao L. engaged in the interaction with Moniliophthora perniciosa, the causing agent of witches' broom disease. Plant Physiol Biochem. 73:254-65.


Pirovani CP, da Silva Santiago A, dos Santos LS, Micheli F, Margis R, da Silva Gesteira A, Alvim FC, Pereira GA, de Mattos Cascardo JC. 2010. Theobroma cacao cystatins impair Moniliophthora perniciosa mycelial growth and are involved in postponing cell death symptoms. Planta. 232(6):1485-97.


Pirovani CP, Carvalho HA, Machado RC, Gomes DS, Alvim FC, Pomella AW, Gramacho KP, Cascardo JC, Pereira GA, Micheli F. 2008. Protein extraction for proteome analysis from cacao leaves and meristems, organs infected by Moniliophthora perniciosa, the causal agent of the witches' broom disease. Electrophoresis. 29(11):2391-401.

Campus Soane Nazaré de Andrade, Rodovia Jorge Amado, Km 16, Bairro Salobrinho CEP 45662-900. - Ilhéus/BA